Mexicana was a low-cost airline based in Mexico City, Mexico. Mexicana, was the first airline established in Mexico and the country's flag carrier. Today, in addition to domestic services, it is the country's largest international airline in terms of most passengers transported, operating services to North America, Central America, the Caribbean, South America and Europe. Its primary hub is Mexico City's Benito Juarez International Airport, with hubs at Cancún International Airport, and Guadalajara's Don Miguel Hidalgo y Costilla International Airport.

Mexicana's main competitor is Aeroméxico, although the two companies "code-share" on several routes and were merged for more than a decade. It is North America's oldest airline and the world's third oldest airline operating under the same name, after the Netherlands' KLM and Australia's Qantas.

The airline joined Oneworld on November 10, 2009